Hill Top Chamber斑試器
Cliantha Hill Top Chamber斑試器被廣泛用于化妝品、香水、薄膜、織物、肥皂、洗滌劑、化學(xué)品以及其他可能直接或間接影響或涉及皮膚的產(chǎn)品領(lǐng)域。
Hill Top Chamber斑試器是一種獲得專利的封閉型皮膚傳遞系統(tǒng)，可用于多種用途，包括：
- 預(yù)測(cè)性斑貼測(cè)試
- 診斷性斑貼測(cè)試
- 皮膚水分評(píng)估
- 皮膚微生物菌群研究
- 動(dòng)物身上的斑貼測(cè)試
系統(tǒng)設(shè)計(jì)/方案
Hill Top Chamber斑試器系統(tǒng)的基本組成部分是一個(gè)模制的塑料腔室，具有足夠的靈活性足以貼合皮膚的輪廓。該腔室有一個(gè)獨(dú)特的雙環(huán)，由一個(gè)外環(huán)和一個(gè)內(nèi)部的柔性法蘭組成，與皮膚表面緊密貼合，以提高閉合性。在腔室里，一個(gè)無(wú)紡布的Webril?墊片容納試驗(yàn)樣品。腔室被夾在方形防粘紙和半封閉的低過(guò)敏性膠布之間，隨時(shí)可以使用。Hill Top腔室可以單獨(dú)提供，也可以以帶有任何數(shù)量小室的多體條狀形式提供。幾乎任何大小或形狀的腔室都可以定制生產(chǎn)。也可提供單獨(dú)的塑料腔室，帶或不帶Webril?墊片。
腔室組成
Hill Top Chamber斑試器采用殼牌石油公司的產(chǎn)品 Kraton? G-2705 制造。 Kraton? 滿足或超過(guò)當(dāng)前 USP 對(duì) VI 類聚合物的物理化學(xué)和生物測(cè)試的要求。該室柔軟且有彈性，從而在測(cè)試材料和皮膚部位之間提供粘合力。 Kraton? 材料已獲得 FDA 批準(zhǔn)使用?？筛鶕?jù)客戶需求提供其他塑料。 Hill Top Chamber 斑試器系統(tǒng)采用 Durapore? 背襯，這是一種“絲狀”膠帶，采用 3M 制造的無(wú)乳膠、低過(guò)敏性粘合劑，具有高強(qiáng)度和粘合力。 Webril? 襯墊為 100% 純棉材質(zhì)。
| 腔室尺寸/配置 |
||||
| 標(biāo)準(zhǔn)/定制 | 小室直徑 | 膠帶尺寸 | 腔室容量 | 當(dāng)前可選型號(hào)* |
| 標(biāo)準(zhǔn) | 19 mm 25 mm |
3×3 cm 4.5 x 4.5 cm |
0.2 ml 0.3 ml |
Plain, Plain w/Pad, Full System |
| 定制* | 33 mm 52.34 mm |
5.5×5.5 cm 7.5 x 5.5 cm |
2.0 ml 2.5 ml |
Domed Plain |
*幾乎可以定制任何尺寸或形狀的腔體。
Hill Top Chambers? 參數(shù)表注意：所有測(cè)量值均為近似值，可能略有差異 |
|
| 19mm Chambers Outside diameter – 19mm? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? Inside diameter – 14mm Webril? insert – 0.50 inches (12.7mm) Weight and Capacity without Webril? Weight full at absolute capacity – 0.577 grams Weight empty – 0.273 Volume at absolute capacity – 0.29 ml H2O Weight and Capacity without Webril? Weight full at level capacity – 0.517 grams Weight empty – 0.273 Volume at level capacity – 0.22 ml H2O Weigh t and Capacity with Webril? Weight at full saturation – 0.480 grams Weight empty – 0.297 Volume at full saturation – 0.17 ml H2O |
25mm Chambers Outside diameter – 25mm? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?Inside diameter – 20mm Webril ? insert – 0.75 inches (19.07mm) Weight and Capacity without Webril? Weight full at absolute capacity – 1.408 grams Weight empty – 0.550 Volume at absolute capacity – 0.86ml H2O Weight and Capacity without Webril? Weight full at level capacity – 1.162 grams Weight empty – 0.550 Volume at level capacity – 0.61ml H2O Weight and Capacity with Webril? Weight at full saturation – 1.158 grams Weight empty – 0.887 Volume at full saturation – 0.27ml H2O |
| 33mm Chambers Outside diameter – 33mm Inside diameter – 26mm Webril ? insert – 0.94 inches (25mm) Weight and Capacity without Webril? Weight full at absolute capacity – 3.995 grams Weight empty – 0.880 Volume at absolute capacity – 3.115ml H2O Weight and Capacity without Webril? Weight full at level capacity – 2.68 grams Weight empty – 0.880 Volume at level capacity – 1.800ml H2O Weight and Capacity with Webril? Weight at full saturation – 2.511 grams Weight empty – 1.010 Volume at full saturation – 1.501ml H2O |
52mm Chambers Outside diameter – 52mm Inside diameter – 46mm Webril? insert – 1.73 inches (44mm) Weight and Capacity without Webril? Weight full at absolute capacity – 8.500 grams Weight empty – 1.867 Volume at absolute capacity – 6.633 ml H2O Weight and Capacity without Webril? Weight full at level capacity – 6.612 grams Weight empty – 1.867 Volume at level capacity – 4.745 ml H2O Weight and Capacity with Webril? Weight at full saturation – 5.940 grams Weight empty – 2.238? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? Volume at full saturation – 3.702 ml H2O |
相關(guān)文獻(xiàn):
Quisno, R.A. and R.L. Doyle. “A New Occlusive Patch Test System with a Plastic Chamber.”
Journal of the Society of Cosmetic Chemists, Vol.34 (1983), pp. 13-19.
(http://journal.scconline.org/pdf/cc1983/cc034n01/p00013-p00019.pdf)
Polikandritou, Maria and David L. Conine.
“Enhancement of the Sensitivity of the Buehler Method by Use of the Hill Top Chamber.”.
Journal of the Society of Cosmetic Chemists, Vol.36 (1985), pp. 159-168
Kaminsky, Marvin, Marylou NM. Szivos and Karen R. Brown. “Application of the Hill Top Patch Test Chamber to Dermal Irritancy Testing in the Albino Rabbit.”
Journal of Toxicology –Cutaneous & Ocular Toxicology, Vol. 5 (1986), pp. 81-87.
Donohue, Janet, ed. “SCC Annual Seminar.” Soap/Cosmetics/Chemical Specialties, Vol. 63 (1987), p. 44.
Kim, Hyun Ok and et. Al. “Skin Absorption from Patch Test Systems.”
Contact Dermatitis, Vol. 17 (1987), pp. 178-190.
(http://www.ncbi.nlm.nih.gov/pubmed/3677660)
Nixon, G.A., E.A. Bannan, T.W. Gaynor, D.H. Johnston and J.F. Griffith.
“Evaluation of Modified Methods for Determining Skin Irritation in Animals and Humans.”
Society of Toxicology Annual Meeting, February 1988
Jirova, Dagmar et al. “Comparison of Human Skin Irritation and Photo-Irritation Patch Test Data with Cellular In-Vitro Assays and Animal In-Vivo
Data”. AATEX 14, Special Issue (2007), p. 359-365(http://altweb.jhsph.edu/wc6/paper359.pdf)
York M, Basketter DA, Cuthbert JA, Neilson L.
“Skin irritation testing in man for hazard assessment–evaluation of four patch systems.”
Human Experimental Toxicology. 1995 Sep;14(9):729-34.
(http://www.ncbi.nlm.nih.gov/pubmed/8579884)
Barel, A.O. et al “A Comparative Study of the Effects on the Skin of a Classical Bar Soap in Normal Use Conditions and In the Soap Chamber Test”
Skin Research and Technology 2001; 7, p.98-104
(http://www.healthmegamall.com/Articles/BabeskinArticle189.pdf)
David Basketter, 1 Dagmar Jírova,2 and Helena Kandárová3
“Review of skin irritation/corrosion Hazards on the basis of human data: A regulatory perspective”.
Interdisciplinary Toxicology. 2012 June; 5(2): 98–104
(http://europepmc.org/articles/PMC3485661/reload=0;jsessionid=QSsIUPKZY1p0U7kcIzXX.2)
請(qǐng)注意:
本產(chǎn)品無(wú)庫(kù)存，需國(guó)外訂購(gòu)，最低起訂量1000個(gè)，貨期一般3周左右。
本頁(yè)面可能僅用于展示產(chǎn)品信息?；诙悇?wù)要求，有關(guān)進(jìn)口產(chǎn)品的銷售我司可能會(huì)用旗下公司抬頭與您簽訂合同、結(jié)算和開(kāi)票，以方便報(bào)稅記賬，請(qǐng)知悉。
